Medical Office Real Estate in San Antonio, TX

San Antonio-New Braunfels Metro

The San Antonio medical office market benefits from the broader strengths of the San Antonio-New Braunfels Metro economy. San Antonio is the seventh-largest city in the United States and one of the fastest-growing metros in Texas. The city's economy is anchored by military installations including Joint Base San Antonio (the largest joint base in the Department of Defense), a robust healthcare and bioscience sector led by the South Texas Medical Center, and a growing cybersecurity industry that has earned the city recognition as a national hub for information security.

Medical office buildings (MOBs) are specialized healthcare facilities designed to house physician practices, outpatient clinics, imaging centers, ambulatory surgery centers, and other medical service providers. Unlike traditional office, medical office benefits from powerful demographic tailwinds as an aging population drives steadily increasing demand for outpatient healthcare services. The ongoing shift of procedures from inpatient hospital settings to lower-cost outpatient facilities has created a structural growth driver for the MOB sector that is largely insulated from economic cycles and remote work disruption. In San Antonio, medical office investors find a market shaped by joint base san antonio is the largest joint military installation in the us, providing economic stability and emerging national hub for cybersecurity with significant government and private sector presence.

San Antonio Market Snapshot

6.8%
Avg Cap Rate
$165
Median Price/SF
$5.1B
Deal Volume
5.5%
Vacancy Rate
1.9%
Population Growth
2.5%
Employment Growth

Key Medical Office Submarkets in San Antonio

Medical Office activity in San Antonio concentrates in several key submarkets, each with distinct characteristics and investment profiles:

Far North CentralDowntown/River WalkThe Pearl/Broadway CorridorMedical CenterI-10 West/UTSANortheast/Schertz

Key Medical Office Metrics

Price Per Square Foot
Cap Rate
Occupancy Rate
Weighted Average Lease Term (WALT)
Tenant Retention Rate
Rent Per Square Foot (NNN or Modified Gross)

How Listserved Helps You Find Medical Office Deals in San Antonio

Listserved automatically ingests broker emails and listing notifications for medical office properties in the San Antonio-New Braunfels Metro area. Our AI extracts asking price, cap rate, NOI, square footage, and other key deal metrics, then matches against your buy box criteria.

Set up alerts for medical office properties in San Antonio and get notified the moment a matching deal arrives in your inbox. Listserved handles the deal flow — you focus on underwriting.

Frequently Asked Questions

What is the average cap rate for medical office properties in San Antonio?

Cap rates for medical office properties in San Antonio vary by submarket, property class, and occupancy levels. The overall San Antonio market average cap rate is approximately 6.8%. Class A properties typically trade at lower cap rates than value-add opportunities.

Why is medical office considered recession-resistant?

Healthcare demand is driven by demographics (aging population) and medical necessity rather than economic conditions. People require medical care regardless of the economic environment, and the shift toward outpatient care continues to accelerate. Medical tenants have long lease terms, high renewal rates, and significant buildout costs that make relocation unattractive. These factors combine to produce stable occupancy and rent collection even during economic downturns.

What is the difference between on-campus and off-campus medical office?

On-campus MOBs are located on or immediately adjacent to a hospital campus, benefiting from direct referral traffic, shared services, and the hospital system brand. They typically command lower cap rates (4.5-5.5%) due to perceived stability. Off-campus MOBs are standalone or in medical parks away from hospitals, typically trading at higher cap rates (5.5-7.0%) but offering potentially higher returns. Off-campus properties may have more diverse tenant bases and less dependence on a single health system.

How does San Antonio compare to Austin for CRE investment?

San Antonio offers significantly lower entry costs and higher cap rates than Austin, making it attractive for yield-oriented investors. While Austin commands a growth premium due to its tech economy, San Antonio provides more stable cash flow driven by military, healthcare, and government employment. The two metros are increasingly connected along the I-35 corridor, and some investors view them as a single megaregion.

What role does the military play in San Antonio's CRE market?

Military and defense spending is a foundational economic driver. Joint Base San Antonio employs over 80,000 military and civilian personnel, creating consistent demand for housing, retail, and office space. The cybersecurity sector that has grown around the military presence adds a technology-driven demand component that diversifies the tenant base beyond government contracts.

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